The major sources of pollution to the Millers River is point source contamination and stormwater. Flooding in particular brings pollutants on the land surface into the river in large quantities. Stormwater runoff also increases sedimentation in the river, affecting the riverbeds and overall life cycles of many aquatic organisms.

Invasive species also pose threats to the watershed, specifically the Japanese Knotweed.

The Millers River was formed over 50 million years ago. Pathways along the river were used by many Native Americans for trade during America's early history. The Pequoig Indians were the first to settle along the river, and now the surrounding area near the southern end of the river is known as "Indian Meadow".

Did You Know?

The river was known as Papacontuckquash which is a Nipmuc word. A map in 1677 is the first record of the river being called Millers River.